While he is not on the Boss Ladder alongside other bosses, Astaroth will be encountered at the end of the new Nightmare Escalations update to Nightmare dungeons.
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Fan-Favorite Boss Astaroth Returns in Diablo 4’s Season 9
Astaroth is a favorite boss fight of many, being the final fight of Act 2, and now he's back and badder than ever, filling the role of top dog in Season 9!