What is the Omnium Folio
The Omnium Folio is a brand new source of power in Patch 12.0.7 which is unlocked after completing a short questline. Once you unlock the Omnium Folio, players can access the "talent tree" by clicking a new button on the mini-map. While previous borrowed power systems were criticized for being tied to pieces of gear that overstayed their welcome such as the Durable Information Securing Container belt in War Within, this system is not tied to gear pieces at all making it easier for developers to tune around the system, or just completely disable it in Season 2.
The Omnium Folio contains 5 nodes, many of which are Choice Nodes. These are unlocked one at a time and are likely weekly timegated, as turning in the first quest mentions that there will be another activity weekly. These nodes seem to be categorized as runes, and act as additional passive damage, healing or stats.
1st Choice
Rune of Void-Touched Orbs - Every 10 sec you attract a void orb to you up to a max of 5. Your attacks send these orbs at your enemy dealing 2745 Cosmic damage for each. Your heal spells send the orbs to the lowest health ally nearby restoring 4116 health for each orb.
Rune of Unleashed Fire - Your spells and abilities have a chance to call down a pillar of fire dealing 2745 Fire damage to an enemy or cauterizing the wounds of a nearby ally restoring 4116 health.
2nd Choice
Rune of Self-Mending - When below 75% health your Core Rune also heals you for 4116 health.
Rune of Void-Tainted Shell - When struck for more than 10% of your max health gain an absorb shield that will absorb up to 18523 damage but 50% of the absorbed amount will linger dealing its damage over 10 sec.
This effect can only occur once every 30 sec.
Rune of Lynxlike Reflexes - When struck in combat increase your speed by 115 for 10 sec.
Cannot occur more than once every 30 sec.
3rd Node
Rune of Lingering - The effects of your Core Rune leave behind a periodic effect that deals 2745 Cosmic damage or restores 4116 health over 8 sec sec based on whether the target is an enemy or ally.
Your Core Rune favors hitting targets that are unaffected by Rune of Lingering.
4th Node
Rune of Critical Power - The effects of your Core Rune increase your Critical Strike rating by 78. This effect may overlap.
Rune of Burning Haste - The effects of your Core Rune increase your Haste rating by 78. This effect may overlap.
Rune of Masterful Cunning - The effects of your Core Rune increase your Mastery rating by 78. This effect may overlap.
Rune of the Versatile Warrior - The effects of your Core Rune increase your Versatility rating by 78. This effect may overlap.
Final Node
Rune of Overload - Increase the effectiveness of your Core Rune ability by 100%.
Rune of Residual Energy - Increase the effectiveness of your Rune of Lingering by 100%.
Rune of Echoes - The effects of your Core Rune leave an echoing curse on your target. After 10 sec, an echo of all the damage and healing done by your Core and Lingering Runes is repeated at 50% effectiveness.
