These are the first new Runewords released in many years, although these won't be the last.
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Ladder Season 1 Runewords in Diablo II: Resurrected Patch 2.4 Analyzed – Best New Runewords, Recommendations
Ladder Season 1, which launches April 28, 2022, will also introduce seven new Runewords -- two Helms and five Weapons. These can only be used by characters playing Ladder during this first Ladder Season of Diablo II: Resurrected. When Ladder Season 1 is over, these Runewords will be available to everyone playing the Expansion version of Patch 2.4.